Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Chromosome CID region map of ATCC 14028 and ATCC 14028-pHXY0908 at 20Kb resolution. A Chromosome CID region map of ATCC 14028. B Chromosome CID region map of ATCC 14028-pHXY0908. Length: the length of a bacterial chromosome; the color bars represent the frequency of DNA fragments interact

Article Snippet: By comparing the location of CID in the two strains, when ATCC 14028-bearing plasmid pHXY0908, the plasmid and bacterial chromosome interacted, and the boundary of bacterial CID Changed significantly.

Techniques:

Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Population analysis assays A Population analysis assays of the Salomella Typhimurium SL1344-pHXY0908 strains using ciprofloxacin. B Population analysis assays of the Klebsiella pneumoniae ATCC 700,603-pHXY0908 strains using ciprofloxacin. C Population analysis assays of the Escherichia coli ATCC 25,922-pHXY0908 strains using ciprofloxacin

Article Snippet: By comparing the location of CID in the two strains, when ATCC 14028-bearing plasmid pHXY0908, the plasmid and bacterial chromosome interacted, and the boundary of bacterial CID Changed significantly.

Techniques:

Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Chromosome CID region map of ATCC 14028 and ATCC 14028-pHXY0908 at 20Kb resolution. A Chromosome CID region map of ATCC 14028. B Chromosome CID region map of ATCC 14028-pHXY0908. Length: the length of a bacterial chromosome; the color bars represent the frequency of DNA fragments interact

Article Snippet: In summary, our study delineated genomic and transcriptomic dynamics during heteroresistance evolution, revealing that transcription regulation is a key driver of ciprofloxacin heteroresistance in S. Typhimurium ATCC 14028 harboring plasmid pHXY0908.

Techniques:

Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Population analysis assays A Population analysis assays of the Salomella Typhimurium SL1344-pHXY0908 strains using ciprofloxacin. B Population analysis assays of the Klebsiella pneumoniae ATCC 700,603-pHXY0908 strains using ciprofloxacin. C Population analysis assays of the Escherichia coli ATCC 25,922-pHXY0908 strains using ciprofloxacin

Article Snippet: In summary, our study delineated genomic and transcriptomic dynamics during heteroresistance evolution, revealing that transcription regulation is a key driver of ciprofloxacin heteroresistance in S. Typhimurium ATCC 14028 harboring plasmid pHXY0908.

Techniques:

Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Chromosome CID region map of ATCC 14028 and ATCC 14028-pHXY0908 at 20Kb resolution. A Chromosome CID region map of ATCC 14028. B Chromosome CID region map of ATCC 14028-pHXY0908. Length: the length of a bacterial chromosome; the color bars represent the frequency of DNA fragments interact

Article Snippet: Population analysis profiling was performed to assess ciprofloxacin heteroresistance in S. Typhimurium ATCC 14028-bearing plasmid pHXY0908 (designated ATCC 14028-pHXY0908).

Techniques:

Journal: BMC Microbiology

Article Title: Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression

doi: 10.1186/s12866-025-04386-6

Figure Lengend Snippet: Population analysis assays A Population analysis assays of the Salomella Typhimurium SL1344-pHXY0908 strains using ciprofloxacin. B Population analysis assays of the Klebsiella pneumoniae ATCC 700,603-pHXY0908 strains using ciprofloxacin. C Population analysis assays of the Escherichia coli ATCC 25,922-pHXY0908 strains using ciprofloxacin

Article Snippet: Population analysis profiling was performed to assess ciprofloxacin heteroresistance in S. Typhimurium ATCC 14028-bearing plasmid pHXY0908 (designated ATCC 14028-pHXY0908).

Techniques: